Top Hotels Near South San Francisco for Convenience

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San Francisco, a city renowned for its iconic Golden Gate Bridge, vibrant cultural scene, and historical landmarks, offers a unique blend of experiences for every traveler. Nestled just a stone's throw away from this bustling metropolis lies South San Francisco, an area that promises convenience and accessibility to the city's numerous attractions without the hustle and bustle. For those looking to immerse themselves in the charm of the Bay Area while enjoying serene accommodations, hotels near South San Francisco present an ideal choice.

Choosing the right hotel in this locale not only provides a peaceful retreat after a day of exploration but also ensures easy access to both downtown San Francisco and the Silicon Valley. Strategically located, these hotels cater to a variety of preferences, whether you're in town for business, pleasure, or a bit of both. With options ranging from luxurious suites to budget-friendly rooms, travelers can find accommodations that perfectly fit their needs and preferences, all within close proximity to South San Francisco.

Moreover, hotels near South San Francisco stand out for their exceptional services and amenities, aimed at making your stay as comfortable and enjoyable as possible. From high-speed internet connectivity for those who need to stay connected to the world, to sumptuous dining options that offer a taste of local and international cuisines, the hospitality here goes above and beyond. This article will guide you through some of the top hotels in the area, providing insights and recommendations to help you make an informed decision for your upcoming trip to San Francisco.

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Our Top 8

(Sorted by rating & number of reviews)

1. The St. Regis San Francisco Hotel
2. Holiday Inn Express San Francisco Airport North, An Ihg Hotel
3. Four Seasons Hotel San Francisco
4. 1 Hotel San Francisco
5. Hilton San Francisco Airport Bayfront - No Resort Fee
6. Best Western Plus Grosvenor Airport Hotel
7. The Ritz-Carlton, San Francisco Hotel
8. Hyatt Regency San Francisco Hotel

Luxury Hotels Near South San Francisco

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San Francisco
Jan 17, 2026 - Jan 18, 2026

The St. Regis San Francisco Hotel

8.9

Good

(85 Reviews)

+ 79 photos
The St Regis San Francisco is another gem for luxury seekers, combining modern sophistication with unbeatable service. Located within easy reach of South San Francisco, this hotel offers guests an urban sanctuary. Each room and suite is meticulously designed, featuring floor-to-ceiling windows that frame the dynamic city skyline. The St Regis boasts an exclusive spa and indoor infinity pool, inviting guests to unwind in style. The hotel's signature restaurant tantalizes with inventive cuisine, while the St Regis Bar serves up innovative cocktails. The butler service, available to all guests, adds a personal touch to the stay, ensuring every need is met with grace and precision.
Address: 125 Third Street
Rating: Good 8.9 (85 Reviews)
Rooms: 260
Price: From 452$

Holiday Inn Express San Francisco Airport North, An Ihg Hotel

7.4

Good

(488 Reviews)

+ 71 photos
The Holiday Inn Express San Francisco-Airport North, located near South San Francisco, is an excellent option for travelers seeking affordability and reliability. The hotel offers a complimentary airport shuttle service, free breakfast, and high-speed internet access, ensuring a comfortable and convenient stay. The rooms are well-appointed, featuring modern amenities and comfortable bedding. The hotel's proximity to major freeways provides easy access to downtown San Francisco and the Silicon Valley, making it an ideal base for budget-savvy travelers.
Address: 373 South Airport Boulevard
Rating: Good 7.4 (488 Reviews)
Rooms: 89
Price: From 115$

Boutique Hotels Near South San Francisco

For those who cherish uniqueness and personalized experiences, boutique hotels near South San Francisco offer a refreshing alternative to larger establishments. These hotels are celebrated for their intimate settings, distinctive character, and meticulous attention to detail. Featuring artistic designs and innovative concepts, each boutique hotel provides a novel approach to hospitality that reflects the vibrant culture of the Bay Area. Ideal for travelers who seek a more personalized stay, these properties offer a blend of luxury, comfort, and originality. In this section, we highlight three boutique hotels that promise an extraordinary stay close to South San Francisco.

Four Seasons Hotel San Francisco

9.1

Good

(157 Reviews)

+ 177 photos
For those who prioritize location, luxury, and exceptional service, the Four Seasons Hotel San Francisco is an ideal choice. Nestled close to South San Francisco, this hotel offers a tranquil retreat in the very heart of the city. Guests can savor elegantly furnished rooms that provide a peaceful haven and magnificent views. The hotel's spa is a sanctuary of health and wellness, offering a wide range of rejuvenating treatments and massages. Culinary experiences at the Four Seasons are memorable, featuring local ingredients and bold flavors. Additionally, the hotel’s proximity to South San Francisco makes it convenient for guests to explore the area's attractions, making the Four Seasons an exceptional base for both leisure and business travelers.
Address: 757 Market Street
Rating: Good 9.1 (157 Reviews)
Rooms: 277
Price: From 45$

1 Hotel San Francisco

8.6

Good

(170 Reviews)

+ 190 photos
Hotel Vitale stands out for its exceptional location and focus on wellness and tranquility. Positioned conveniently near South San Francisco, this waterfront hotel offers panoramic views of the Bay Bridge and the city skyline. Rooms are designed with relaxation in mind, featuring natural elements and soothing colors. The rooftop terrace provides a breathtaking setting for morning yoga sessions, while the spa specializes in treatments that rejuvenate body and mind. Dining at Hotel Vitale emphasizes freshness and sustainability, with dishes that showcase the best of California’s seasonal produce. This boutique hotel is an urban oasis for those looking to relax and recharge while staying close to South San Francisco.
Address: 8 Mission Street
Rating: Good 8.6 (170 Reviews)
Rooms: 200
Price: From 324$

Business Hotels Near South San Francisco

Business travelers will find that staying near South San Francisco not only puts them in a prime location to access major corporate hubs but also offers superior accommodation tailored to their specific needs. These hotels are equipped with state-of-the-art business centers, meeting rooms, and high-speed internet, ensuring productivity remains uninterrupted. Furthermore, these establishments understand the fast-paced nature of business travel and offer amenities like express check-in/check-out and transportation services to local offices and convention centers. Here, we showcase three hotels that stand as pillars of convenience and efficiency for the business visitor to South San Francisco.

Hilton San Francisco Airport Bayfront - No Resort Fee

7.5

Good

(1314 Reviews)

+ 188 photos
The Hilton San Francisco Airport Bayfront excels in providing a seamless stay for business travelers. Its proximity to the airport and South San Francisco's biotech companies makes it an ideal choice for those on tight schedules. The hotel boasts comprehensive business facilities, including versatile meeting spaces and a 24-hour business center. Rooms are designed with comfort and practicality in mind, offering work desks and ergonomic chairs. The on-site restaurant ensures that guests can enjoy quality meals without venturing far, while the fitness center offers a chance to unwind. The Hilton's commitment to professional service ensures that every business need is met with excellence.
Address: 600 Airport Blvd.
Rating: Good 7.5 (1314 Reviews)
Rooms: 400
Price: From 104$

Best Western Plus Grosvenor Airport Hotel

7.7

Good

(1463 Reviews)

+ 181 photos
The Best Western Plus Grosvenor Airport Hotel provides guests with affordable accommodations, a mere distance from South San Francisco. The hotel offers complimentary breakfast, a fitness center, and an outdoor pool, making it an exceptional value for budget-conscious travelers. Rooms are equipped with comfortable beds and modern amenities, ensuring a restful stay. The hotel also features a business center and free airport shuttle service, adding to its convenience for guests on the go.
Address: 380 S Airport Boulevard
Rating: Good 7.7 (1463 Reviews)
Rooms: 206
Price: From 121$

Budget-Friendly Hotels Near South San Francisco

Travelers on a budget looking for accommodations near South San Francisco will be pleased to find a selection of hotels that offer comfort and convenience without breaking the bank. These hotels are perfect for those who prioritize value, featuring essential amenities such as complimentary Wi-Fi, on-site parking, and access to public transportation. Despite their affordability, these establishments do not compromise on quality or service, ensuring a pleasant stay for tourists and business visitors alike. Below are three hotels that offer excellent value close to South San Francisco.

The Ritz-Carlton, San Francisco Hotel

9.0

Good

(435 Reviews)

+ 194 photos
Situated just a short drive from South San Francisco epitomizes timeless luxury with its elegant interiors, impeccable service, and a Michelin-starred restaurant. Guests can indulge in beautifully appointed rooms that offer breathtaking views of the cityscape. The hotel's spa features treatments inspired by the region's traditions and natural ingredients, providing a serene escape from the urban hustle. Dining at the Ritz-Carlton is an affair to remember, with its farm-to-table philosophy ensuring every dish is as fresh as it is delicious. For business travelers, the hotel offers expansive meeting spaces equipped with the latest technology. Staying at The Ritz-Carlton means experiencing San Francisco’s luxury at its finest, all within a convenient distance from South San Francisco.
Address: 600 Stockton Street
Rating: Good 9.0 (435 Reviews)
Rooms: 336
Price: From 359$

Hyatt Regency San Francisco Hotel

8.7

Good

(1685 Reviews)

+ 213 photos
Strategically located to offer quick access to both the airport and South San Francisco's corporate sector, the Hyatt Regency San Francisco Airport is a favorite among business travelers. This hotel stands out for its expansive event spaces, capable of hosting anything from small meetings to large conferences. Guests can take advantage of the 24-hour market for on-the-go meals and the complimentary airport shuttle service. The rooms offer a tranquil retreat, with soundproof windows and plush bedding, allowing for restful nights between busy days. The Hyatt Regency also features an outdoor pool and fitness center, providing guests with options to relax and recharge.
Address: 5 Embarcadero Center
Rating: Good 8.7 (1685 Reviews)
Rooms: 804
Price: From 291$